Thermo Fisher Scientific Demonstrates Success Of Its Liquid Chromatography Tandem Mass Spectrometry Solution At Ameritox

Thermo Fisher Scientific Inc., the world
leader in serving science, announced the success of its liquid
chromatography tandem mass spectrometry (LC-MS/MS) solution at Ameritox, a
leading provider of forensic and specialty toxicology laboratory services.
The Thermo Scientific TSQ Quantum Access triple quadrupole mass
spectrometer, combined with the Thermo Scientific Aria TLX-4 system, uses
TurboFlow and multiplexing technologies to offer the industry's most
advanced, most sensitive analytical method for clinical research labs like
Ameritox. By implementing this advanced LC-MS/MS method, Ameritox has
reduced the amount of time spent on sample preparation and increased its
mass spectrometry throughput for forensic and specialty toxicology
assessments.



The Thermo Scientific TurboFlow technology uses turbulent flow
chromatography to separate analytes from biological matrices prior to MS/MS
analysis. Unlike traditional technologies, the TurboFlow method injects the
sample directly onto a narrow diameter TurboFlow column. By eliminating
extraction, derivitization and evaporation, Ameritox has reduced the lengthy
sample preparation time traditionally associated with other methods.



The Aria TLX-4 is the only truly independent, parallel, multi-channel high
performance liquid chromatography (HPLC) system in the industry. It utilizes
Thermo Scientific Aria Software to manage all aspects of the process and
allows as many as four sample batches to run at the same time, each with a
unique method. By maximizing this multiplexing system, Ameritox has
recognized increased productivity - essentially the output of four separate,
parallel LC systems from a single mass spectrometer - and avoided the high
capital costs associated with other methods.



"We are very pleased with the performance of the Aria TLX-4 multiplexing
system with TurboFlow technology," commented Dr. James Bourland, laboratory
director, Ameritox. "With the assistance of the Thermo Fisher Scientific
field services staff, we have successfully transferred two high-volume
confirmations to LC-MS/MS. As a result, we have realized efficiencies by
eliminating extractions and reducing the analysis time and turnaround time.
In addition, the quality and reliability of the LC-MS/MS data is superior to
our previous method."



Thermo Fisher Scientific has a comprehensive range of clinical solutions for
a variety of applications. Featuring chromatography and mass spectrometry
techniques under its premier Thermo Scientific brand, in addition to the
Microgenics and Athena specialty brands, the company is now a top-10 player
in the clinical diagnostics market. "We are thrilled with the success
Ameritox has realized through our comprehensive solution," comments Jeff
Zonderman, director LC-MS clinical and toxicology, Thermo Fisher Scientific.
"The benefits derived from the Aria TLX-4 multiplexing system powered by
TurboFlow technology, combined with the sensitivity and confidence of the
TSQ Quantum Access, set us apart in the marketplace."
















For more information on the Thermo Scientific LC-MS/MS multiplexed
technology, please call +1 800-532-4752, email analyzethermofisher or
visit thermo/clintox.



Mass Spectrometers are general purpose laboratory instruments. They have
not been cleared or approved by the United States Food and Drug
Administration, the European IVD Directive or any other agency for
diagnostic, clinical or other medical use.



Thermo Scientific is part of Thermo Fisher Scientific, the world leader in
serving science.



About Thermo Fisher Scientific


Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving
science, enabling our customers to make the world healthier, cleaner and
safer. With annual revenues of $10 billion, we have more than 30,000
employees and serve over 350,000 customers within pharmaceutical and biotech
companies, hospitals and clinical diagnostic labs, universities, research
institutions and government agencies, as well as environmental and
industrial process control settings. Serving customers through two premier
brands, Thermo Scientific and Fisher Scientific, we help solve analytical
challenges from routine testing to complex research and discovery. Thermo
Scientific offers customers a complete range of high-end analytical
instruments as well as laboratory equipment, software, services, consumables
and reagents to enable integrated laboratory workflow solutions. Fisher
Scientific provides a complete portfolio of laboratory equipment, chemicals,
supplies and services used in healthcare, scientific research, safety and
education. Together, we offer the most convenient purchasing options to
customers and continuously advance our technologies to accelerate the pace
of scientific discovery, enhance value for customers and fuel growth for
shareholders and employees alike.

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